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MSCell4Vet Stem Cell Laboratory

Our website provides information about an innovative treatment option, namely stem cell treatment to allow animals live a full life free of pain. Our mission is to improve the efficiency of tissue stem cell therapy and to underpin its usefulness in veterinary medicine with novel scientific results.

In May 2015, we submitted a patent claim for our allogeneic stem cell therapy. Up to that date, a total of 62 cases of moderate or severe osteoarthritis have been treated in dogs employing this minimally-invasive MSC transplantation. The results are summarized in the figures below.

Our first dog, who suffered from severe elbow dysplasia, received stem cell transplantation via injection in May 2013. This dog has been symptom-free without medications ever since.

The first stem cell transplantation in a horse was performed in January 2015 to treat ankle arthrosis; since then, this horse has been able to race again.

Scientific background

Veterinarians involved

Owing to their plasticity, mesodermal stem cells (MSC) can form mesodermal bone, cartilage and fat cells in the presence of appropriate factors (Murray IR et al. 2014 Bone Joint J 96-B: 291-8). Although this ability to differentiate has mainly been shown under in vitro culture conditions, it has been recently demonstrated that treatment of human osteoarthritis with MSC was followed by the formation of hyaline cartilage in the knee joint (Jo CH et al. 2014 Stem Cells 32: 1254-66).

Please visit our qualified veterinarians' page to help determine if stem cell therapy is right for your dog, cat or horse.

   

Success stories

Frequently asked questions

Bono, a golden retriever has been the first dog in Hungary transplanted with stem cells to treat his severe elbow dysplasia. He was charming, lively and playful like all puppies, but at the age of six months he started limping more and more frequently.

 

Is your dog limping on his front legs?

Does he have elbow dysplasia?

 

   

 

Elbow dysplasia is a developmental disorder affecting hundreds of dogs nationwide and annually.  Elbow dysplasia primarily occurs in medium and large dogs, and develops at around 6 months of age. It leads to irreversible damage to the joints and osteoarthritis(cartilage wear, bone surface abrasion). The result is pain and lameness. The treatments used by veterinarians are surgery, anti-inflammatory and analgesic drugs, cartilage-fortifying supplements and physiotherapy.

Consideration should be given to the application of the therapeutic treatment utilizing adult tissue stem cells (MSC). These stemcells are able to differentiate not only into bone, cartilage and fat cells but also into muscle and tendon cells, thus they can be used to treat orthopedic diseases. Healing is also promoted by the considerable anti-inflammatory effect of stem cells.
The intervention involves moderate risk. Stem cell transplantation is done under general anesthesia; the patient is injected directly at the injured part of the body.

In the United States and Canada, dogs suffering from elbow dysplasia have been treated with stem cells for many years. Regenerative medicine could achieve an asymptomatic period of six-ten months or significant improvement. For the method employed there, the stem cells are isolated from the patient's fatty tissue in a centralized way. In hereditary elbow dysplasia, stem cells, too, carry the genetic defect, and hence we assume that the cartilage derived from MSCs also undergoes a degenerative process limiting therapeutic effect. In the procedure we propose, the fatty tissue needed for MSC isolation is derived from dogs that do not suffer from orthopedic diseases. Therefore, in our method, orthopedically healthy stem cells are transplanted locally into the joint of the sick dog, achieving a longer symptom-free period or, hopefully, even full recovery. 

In addition, stem cell transplantation is also suitable for the treatment of cartilage, tendon and bone injuries in horses and cats.

Work in our state of the art laboratory is performed with the utmost care. Please take a look at our video about the whole process from stem cell isolation to stem cell transplantation.

 If you have further questions, please contact us!