• scientific-background

Stem cells treatment

Owing to their plasticity, mesenchymal stem cells (MSC) can form mesodermal bone, cartilage and fat cells in the presence of appropriate factors (Murray IR et al. 2014 Bone Joint J 96-B: 291-8). 

Although this ability to differentiate has mainly been shown under in vitro culture conditions, it has been recently demonstrated that treatment of human osteoarthritis with MSC was followed by the formation of hyaline cartilage in the knee joint (Jo CH et al. 2014 Stem Cells 32: 1254-66).

In the case of collagenase-induced tendonitis in horse, the structure of regenerating tendon in animals treated with autologous MSC was identical with that of healthy tendon (Nixon AJ et al. 2008. Am. J. Vet. Res. 69:928-37).

This demonstrates that MSC is also capable of differentiating into physiological cartilage in vivo, and that it can also be used in other orthopedic injuries. Not only this ability, but also its considerable anti-inflammatory effect contributes to the treatment of osteoarthritis (Shi Y et al. 2010 Cell Res 20: 510-18).

Based on the data in the literature it can be established that MSC transplantation does not elicit serious adverse effects either systemically or locally (Jo CH et al. 2014 Stem Cells 32: 1254-66).


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